The southern extension of the Mid-City Line connects Cicero with Midway Airport, tying together medium and low density blue collar and middle class communities on the West and Southwest Sides, consisting largely of single-family residences and two-flats. Again, it utilizes the Chicago Belt Line Railway over most of its length.

This extension creates an important link between the two major regional airports, and provides improved access for the service-related jobs in the surrounding communities. The relatively wide spacing of stations reflects the lack of commercial and residential destinations due to the industrial nature of the corridor, plus the intersection of the also-industrial Chicago River South Branch corridor.